Various academic and experiment reports about phototherapy

Various studies providing depth and understanding about the treatments outlined

History - Frieman, father of LLLT

History, Mechanism, Dose, Mitochondrial, Anti-inflammatory

History, Mechanism, Dose, Mitochondrial, Anti-inflammatory

Visible Light therapy vs. Near Infrared Light therapy

History, Mechanism, Dose, Mitochondrial, Antinflammatory

Sunlight Incidence, Vitamin D Deficiency, and Alzheimer's Disease.

Artificial Light and Cancer - Mal Illumination

Artificial Light and Obesity

Light at night clock and metabolism

History, Mechanism, Dose, Mitochondrial, Antinflammatory

Diabetic Neuropathy

Hair Loss

Wound Healing

dairy cattle, cat tongue

Wound healing LED shows significant speed of recovery with 633nm.


Dermal Abrasions



Transcranial effect of LED Injury

Testosterone replacement


Light therapy modulates serotonin levels and blood flow in women with headache. A preliminary study.

Dermal Abrasions



Efficacy of Low-Level Laser Therapy in the Treatment of Temporomandibular Myofascial Pain: A Systematic Review and Meta-Analysis.


Comparison of Red and Infrared Low-level Laser Therapy in the Treatment of Acne Vulgaris.

Sunlight Incidence, Vitamin D Deficiency, and Alzheimer's Disease.


Long term study

Psychological benefits 2 and 4 weeks after a single treatment with near infrared light to the forehead: a pilot study of 10 patients with major depression and anxiety:

Transcranial Laser Stimulation as Neuroenhancement for Attention Bias Modification in Adults with Elevated Depression Symptoms.

Low-Level Laser Irradiation Improves Depression-Like Behaviors in Mice.


Saltmarche AE, Naeser MA, Ho KF, Hamblin MR, Lim L. Significant Improvement in Cognition in Mild to Moderately Severe Dementia Cases Treated with Transcranial Plus Intranasal Photobiomodulation: Case Series Report. Photomed Laser Surg.

dementia, memory, moodGeneral Brain Health & Cognitive Performance Transcranial infrared laser stimulation produces beneficial cognitive and emotional effects in humans.

Emotional responses and memory performance of middle-aged CD1 mice in a 3D maze: Effects of low infrared light

Improving executive function using transcranial infrared laser stimulation.

Cognitive enhancement by transcranial laser stimulation and acute aerobic exercise.

Neurological and psychological applications of transcranial lasers and LEDs.

Alzheimers Disease

Low-Level Laser Therapy Ameliorates Disease Progression in a Mouse Model of Alzheimer’s Disease's_Disease

Photobiomodulation with near infrared light mitigates Alzheimer's disease-related pathology in cerebral cortex - evidence from two transgenic mouse models.

Low-level laser therapy rescues dendrite atrophy via upregulating BDNF expression: implications for Alzheimer's disease.


Is bipolar disorder an inflammatory condition? The relevance of microglial activation.


mice subjected to acute arthritis condition.

Effect of low-level laser therapy on the expression of inflammatory mediators and on neutrophils and macrophages in acute joint inflammation.

Bells Palsy -


The effects of low level laser therapy (LLLT) on the testis in elevating serum testosterone level in rats

Aging Skin

Regulation of Skin Collagen Metabolism In VitroUsing a Pulsed 660 nm LED Light Source: Clinical Correlation with a Single-Blinded Study

Low-level laser (light) therapy (LLLT) in skin: stimulating, healing, restoring HEALTH

Low Level Laser Therapy: A Panacea for oral maladies

Shining light on the head: Photobiomodulation for brain disorders

Significant Improvement in Cognition in Mild to Moderately Severe Dementia Cases Treated with Transcranial Plus Intranasal Photobiomodulation

NUTS AND BOLTS OF LLLT - Survey of Basically Everything treated by LLLT


Biphasic Dose Response in Low Level Light

The role of nitric oxide in low level light therapy

How Mitochondria absorb visible light


A controlled trial to determine the efficacy of red and near-infrared light treatment in patient satisfaction, reduction of fine lines, wrinkles, skin roughness, and intradermal collagen density increase.

Effects of radiofrequency, electroacupuncture, and low-level laser therapy on the wrinkles and moisture content of the forehead, eyes, and cheeks

Low-level laser (light) therapy (LLLT) in skin: stimulating, healing, restoring.


Low-Level Laser Therapy for Fat Layer Reduction: A Comprehensive Review

“Overweight and obesity.” Centers for Disease Control and Prevention (2007). Available:

Sene-fiorense M, Duarte FO, De aquino junior, et al. The potential of phototherapy to reduce body fat, insulin resistance and “metabolic inflexibility” related to obesity in women undergoing weight loss treatment. Lasers Sung Med. 2015;47(7):634-42

Ger Med Sci. 2006 Jul 11:4; Doc05. Influence of water-filtered infrared-A (wiRA) on reduction of local fat and body weight by physical exercise. Mockel F, Hoffman G, Obermuller R, Drobnik W,Schmitz G.

Mcrae E, Boris J. Independent evaluation of low-level laser therapy 635nm for non-invasive body contouring of the waist, hips and thighs. Lasers Surg Med. 2013;45(1):1-7.

635nm - 660nm for Fat Loss

Low-Level Laser Therapy for Fat Layer Reduction: A Comprehensive Review

Health After Cancer

Warburg O. Uber den Stoffweschsel der Hefe. Bianconi E., Piovesan A, Facchin F, et al. An estimation of thenumber of cells in the human body. Ann Hun Biol 2013:40(6):463-71

Li, Y., Park, JS., Deng, JH. Et al. Cytochrome c oxidase subunit IV is useful for assembly and respiratory function of the enzyme complex. J Bioenerg, Biomember (2006)38;283

Brown GC, Borutalite V. Nitric Oxide, cytochrome c, and mitochondria. Biochem Soc. Symp. 1999:66;17-25


Therapeutic photobiomodulation: nitric oxide and a novel function of mitochondrial cytochrome c oxidase.

Inflammation in general:

Mechanisms and applications of the anti-inflammatory effects of photobiomodulation

Veterinary Medicine and Photobiomodulation

An investigation into the depth of penetration of low level laser therapy through the equine tendon in vivo


Photobiomodulation for the treatment of retinal diseases: a review

Photobiomodulation reduces drusen volume and improves visual acuity and contrast sensitivity in dry age‐related macular degeneration

Mitochondrial signal transduction in accelerated wound and retinal healing by near-infrared light therapy.

Effect of equal daily doses achieved by different power densities of low-level laser therapy at 635 nm on open skin wound healing in normal and diabetic rats.

Viral Warts

Review of transcranial photobiomodulation for major depressive disorder: targeting brain metabolism, inflammation, oxidative stress, and neurogenesis


Plantar Warts




Improved Sleep & PTSD

Thyroid Tissue Generation Performance and Recovery

Effect of low-level laser therapy on muscle adaptation to knee extensor eccentric training

Low-level laser (light) therapy (LLLT) on muscle tissue: performance, fatigue and repair benefited by the power of light. Cleber Ferraresi et al. 2012

Does Phototherapy Enhance Skeletal Muscle Contractile Function and Postexercise Recovery? A Systematic Review. Paul A Borsa et al. 2013

Verifies the benefit of LLLT in all phases of muscle recovery: 107.

Photobiomodulation therapy for the improvement of muscular performance and reduction of muscular fatigue associated with exercise in healthy people: a systematic review and meta-analysis.

Photobiomodulation Therapy Improves Performance and Accelerates Recovery of High-Level Rugby Players in Field Test: A Randomized, Crossover, Double-Blind, Placebo-Controlled Clinical Study. Pinto HD et al. 2016

Light-emitting diode therapy in exercise-trained mice increases muscle performance, cytochrome c oxidase activity, ATP and cell proliferation. Ferraresi C et al. 2016

Effects of Light-Emitting Diode Therapy on Muscle Hypertrophy, Gene Expression, Performance, Damage, and Delayed-Onset Muscle Soreness: Case-control Study with a Pair of Identical Twins. Ferraresi C et al. 2016

Diabetic Neuropathy